2 edition of Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions found in the catalog.
Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions
Larry Wayne Hall
Written in English
|The Physical Object|
|Pagination||1 v., 99 leaves|
|Number of Pages||99|
Dissolution Rate Studies on Solid Dispersions Dissolution rate of mefenamic were studied using an USP XXIII six station dissolution rate test apparatus (Electro Lab). Paddle stirrer at a speed of 50 rpm and temperature of 37± 10C were used in each Size: KB. Thus, the soliddispersion technique can be successfully used for improvement of dissolution of clomiphene words: Clomiphene citrate (CC), Solid Dispersion (SD), Polyethylene glycol (PEG).Introduction improve the dissolution properties of poorly water-The rate and extent of dissolution of the drug from any soluble drugs, which was. Read "Preformulation study of etoposide: II. Increased solubility and dissolution rate by solid-solid dispersions, International Journal of Pharmaceutics" on DeepDyve, the largest online rental service for scholarly research with thousands . The tendency of highly supersaturated solutions of poorly water-soluble drugs to undergo liquid–liquid phase separation (LLPS) into drug-rich and water-rich phases when the concentration exceeds the amorphous solubility, for example, during dissolution of some amorphous solid dispersions, is thought to be advantageous from a bioavailability enhancement perspective. Cited by: 4.
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Abstract. A ground mixture of griseofulvin and microcrystalline cellulose was prepared by grinding them in a vibrational ball mill. The dissolution rate and bioavailability of griseofulvin from the ground mixture were shown to be significantly greater than those from a micronized griseofulvin by: A marked increase of the dissolution rate and solubility of griseofulvin contained in these solid dispersions was observed compared with that of drug.
Other approach include shielding the drug from the gastric metabolism and targeted drug release to obtain optimal drug absorption. In this study, a poorly water-soluble model drug, griseofulvin, was encapsulated as disordered solid dispersions into Eudragit L enteric polymer micromatrix particles, which were produced by by: In this study, a poorly water-soluble model drug griseofulvin was encapsulated as disordered solid dispersions into Eudragit® L enteric polymer.
In this study, the supersaturation behavior of griseofulvin (GF) was investigated, followed by investigation of the dissolution and oral absorption behaviors of GF ASDs with an emphasis on the degree of supersaturation.
Materials and methods Materials. Griseofulvin (GF) was purchased from Fuji Film Wako Pure Chemicals (Osaka, Japan).Author: Kohsaku Kawakami, Kyosuke Suzuki, Masafumi Fukiage, Maki Matsuda, Yohei Nishida, Michinori Oikawa, T.
Win Loung Chiou and Sarfaraz Niazi, Phase diagram and dissolution‐rate studies on sulfathiazole‐urea solid dispersions, Journal of Pharmaceutical Sciences, 60, 9, (), (). Wiley Online LibraryCited by: The dissolution rate of GF from HPMCAS solid dispersions was studied.
The results showed higher dissolution rate of drug from the solid dispersions. About 90% of GF was dissolved within the first Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions book min of the by: Dissolution case studies of weak base, weak acid, and neutral compounds are presented, illustrating a rational approach for the development and implementation of the desired dissolution characteristics for the amorphous drug product performance.
Oral absorption of griseofulvin in dogs: increased absorption via solid dispersion in Cited by: New Method of Solid-state Dispersion for Increasing Dissolution Rates Sir: The authors have recently reported on the potential vallue of solid-state dispersion, viz., solid solutions, in enhancing the dissolution rate and gastrointestinal absorption of drugs ().
Amorphous solid dispersions are used as a strategy to improve the bioavailability of poorly water-soluble compounds. When formulating with a polymer, it is important not only for the polymer to stabilize against crystallization in the solid state, but also to improve the dissolution profile through inhibiting crystallization from the supersaturated solution generated by dissolution Cited by: Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry.
• Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems •. Griseofulvin is deposited in keratin precursor cells within 4–8 hr of administration PO.
Sweat and transdermal fluid loss appear to play an important role in griseofulvin transfer in the stratum corneum. When these cells differentiate, griseofulvin remains bound and persists in keratin, making it resistant to fungal invasion.
For this reason, new growth of hair, nails, or horn is the. The objective of this study was to prepare solid dispersions by fusion and co-precipitation and evaluate, in vitro, the influence of these preparations of PZQ on solubility, dissolution rate, and intestinal absorption.
MATERIAL AND METHODS. Praziquantel (PZQ) was obtained with a purity of %, from Induken Quimica Ltda (Brazil). The specifically designed in-vivo dissolution study will be required in solid dispersion system to access the absorption rate, and hence its bioavailability and to demonstrate the bioequivalence ultimately.
Advantages of Solid Dispersions: Improving drug bioavailability by changing their water solubility has been possible by solid dispersion. Dissolution Studies. Dissolution studies were carried out in USP Apparatus II (VKVankel Industries, Cary, NC) at rpm in ml deionized water (pH ) at 37°C (n = 6).The apparatus was equipped with an eight channel peristaltic pump and a UV spectrophotometer for determination of the drug concentration and for return of sample to the dissolution by: Clonazepam is an anticonvulsant and anxiolytic drug characterized by poor solubility and rapid absorption.
The purpose of the study was to improve the solubility of clonazepam in solid dispersions by incorporating hydroxypropyl methyl cellulose (HPMC) and poloxamer The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited.
For this reason, the production of amorphous drugs with adequate stability remains a major challenge and formulation strategies based on solid Cited by: From the dissolution study it was observed that only 26% of the drug was released after 2 h from the pure EFV sample. In comparison to this the dissolution rates of all the solid dispersions were remarkably enhanced (Prate from solid dispersions can be due to several reasons.
rate limiting step in the process of absorption. In such case, we can improve their solubility and dissolution rate. To study the effect of surfactant on the solid dispersion of poorly water soluble drug.
Keywords: Solubilisation, solid dispersion, Polyehylene Glycol, bioavailability, dissolution rate etc. INTRODUCTIONFile Size: KB. Solid dispersion (SD), wherein one or more poorly soluble drugs are dispersed in hydrophilic polymers, is an effective method for improving the solubility and bioavailability of poorly soluble compounds [30,31,32].Hydrophilic polymer properties determine drug dissolution capacities .SD polymers [34,35,36,37,38,39], such as polyethylene glycol, polyvinylalcohol, cellulose Cited by: 3.
It has been reported that 40% of the marketed products and up to 70% of the new chemical entities (NCE) are poorly water-soluble . Intestinal absorption of these drugs turns out to be rate-limiting due to the poor aqueous solubility, which resulted in low bioavailability.
Griseofulvin, Indomethacin and Oxazepam. The ability of solid dispersions to afford drug release as fine, dispersed particles has resulted in improvements in dissolution rates of poorly water soluble drugs which have also been reflected in increases in oral bioavailability.
The increase in dissolution rate and solubility provided by solid. Applications of solid dispersions Bindu Yadav 1* and Y. Tanwar 2 therefore increases the dissolution rate and absorption of drugs.
drug crystallizes from drug-polymer miscible mixture is greater than the rate at which drug-polymer fluid mixture solidifies. (c) Amorphous Solid dispersion: If the drug-polymer fluid mixture is cooled at.
by formulating solid enhance the solubility of poorly water soluble drug,by means of solubilising agent. In case of poorly water soluble drug, dissolution may be the rate limiting step in the process of absorption.
In such case,we can improve their solubility and dissolution study the effect of surfactant on. these drugs dissolution is the rate limiting step to absorption. Hence, the hypothesis has been that the rate of absorption in vivo will be concurrently accelerated with an increase in the rate of drug dissolution (Dhirendra et al., ).
Different kinds of polymers used in second generation solid dispersions. Polymer. commonly used to increase dissolution rate and thereby oral absorption and bioavailability of low water soluble drugs, there is practical limitation to these techniques. Among numerous ways of enhancing drug dissolution solid dispersion of drug in a water soluble polymer is one of the promising technique5.
Solid dispersion (SD) is defined as. CHAPTER 9 BIBLIOGRAPHY BIBLIOGRAPHY 1. Goldberg A., Gibaldi M. and Kanig L.: Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II experimental evaluation of a solid dispersions of griseofulvin, J.
Pharm. Sci., ; pp Pharmaceutical Solid Dispersion Technology. Muhammad J. Habib Methods of Preparing Solid Dispersions. piroxicam polyethylene glycol polymers polyvinylpyrrolidone poorly water-soluble drugs powder precipitation properties rate of dissolution ratio reduced release of drugs Sekikawa solid dispersion systems solid solution solvate Reviews: 2.
The purpose of this study was to prepare solid dispersion by Kneading method, to improve the dissolution rate of Mesalamine. It was postulated that, if the drug is only slightly soluble in water, the dissolution process could be the rate-limiting step in the absorption of drug thus resulting in poor bioavailability.
Invasive antifungal infections are reasons for morbidity and mortality in immunogenic patients worldwide. Posaconazole is a most promising antifungal agent against all types of invasive infections with high % of cure rate.
The marketed suspension formulation has low bioavailability and is needed to be taken with food. In this paper, PCZ hot melt extruded amorphous solid Cited by: The main purpose of this research was to study the mechanism of drug release from solid dispersions of albendazole, giving special emphasis to particle size of the drug in solid dispersions.
Solid dispersions were prepared using three different carriers, mixing ratios and methods in an attempt to improve the solubility and dissolution rate of. Keyphrases Solid dispersion systems-review 0 Dispersions, solid systems-review 0 reduce the particle size and increase rates of dissolution and absorption was first demonstrated by Sekiguchi were used (34, 35).
The disadvantage is that many or of of of 9, 0. and of Simple Journal of Pharmaceutical Sciences. of No. - c of of Cited by: Solid dispersions have been used as a strategy to improve the solubility, dissolution rate, and bioavailability of poor water-soluble drugs.
The increase of the dissolution rate presented by (5Z)(4-chloro-benzyl)(4-nitro-benzylidene)-imidazolidine-2,4-dione (LPSF/FZ4) from the solid dispersions is related to the existence of intermolecular interactions of hydrogen bond.
On the other hand, the dissolution rate of simvastatin from solid dispersion system (ratios ofand ) exhibited a significant improvement of dissolution rate within the first 45 minutes,in which approximately %, % and % of simvastatin had been dissolved, : Erizal Zaini, Alessandro Evert, Maria Dona Octavia.
The prepared dispersions showed marked increase in the saturation solubility and dissolution rate of celecoxib than that of pure drug. The dispersions with mannitol () by fusion method showed faster dissolution rate (%) as compared to other solidFile Size: KB. abstract. Amiodarone HCl is an antiarrhythmic agent, which has low aqueous solubility and presents absorption problems.
This study aimed to develop inclusion complexes containing hydrophilic carriers PEGand by fusion and kneading methods in order to evaluate the increase in solubility and dissolution rate of amiodarone HCl.
The objective of this study was to improve dissolution rate of celecoxib which was water-insoluble drug. Solid dispersions were prepared by spray drying as the solvent evaporation method. The dissolution behavior of solid dispersions was compared with Celebrex ® (Pfizer) as a control group in simulated gastric juice (pH% by: CYP3A4 is the key enzyme for the metabolism of SIM in liver.
The aim of the present study was to improve solubility, dissolution rate and antihyperlipedimic activity of SIM using solid dispersion with pluronic F Methods: The solid dispersions in different w/v ratio were prepared by solvent evaporation : Amit R.
Tapas, Vikas P. Ingle, Pravin S. Kawtikwar, Dinesh M. Sakarkar. Solid dispersions The use of solid dispersions for enhancing drug solubility has become a popular strategy in recent years because of its applicability to a wide range of drug types and dosing requirements.
There are several types of solid dispersion that have been used for pharmaceutical purposes, as summarized in Table 1. A broad and comprehensive study of the various solid forms of drugs is needed to enhance their translation into the clinic.
Therefore, the most suitable solid form must be taken into consideration regarding ex vivo and in vivo stability, targeting, solubility, dissolution rate, and bioavailability. High throughput physicochemical profiling for drug discovery. J Pharm Sci. ; – Khan GM, Zhu JB.
Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc. Miniaturised Dissolution. Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: Polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs.
A DoE study to understand partition rate in a biphasic system. Intrinsic dissolution rate (mg/cm2 /min) is characteristics of each solid compound in a given solvent under fixed hydrodynamic conditions Intrinsic dissolution rate helps in predicting if absorption would be dissolution rate-limited > 1 mg/cm2 /min --> not likely to present dissolution rate-limited absorption problems.